Slobodan Paessler Selected Research

American Hemorrhagic Fever (Bolivian Hemorrhagic Fever)

1/2022	Machupo Virus with Mutations in the Transmembrane Domain and Glycosylation Sites of the Glycoprotein Is Attenuated and Immunogenic in Animal Models of Bolivian Hemorrhagic Fever.
1/2020	The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome.
1/2017	Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression.
1/2016	Machupo Virus Expressing GPC of the Candid#1 Vaccine Strain of Junin Virus Is Highly Attenuated and Immunogenic.
6/2015	The glycoprotein precursor gene of Junin virus determines the virulence of the Romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever.
1/2014	RIG-I enhanced interferon independent apoptosis upon Junin virus infection.
12/2010	Mice lacking alpha/beta and gamma interferon receptors are susceptible to junin virus infection.

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Slobodan Paessler Research Topics

Disease

43	Infections 05/2022 - 07/2005
11	COVID-19 12/2022 - 01/2020
10	Virus Diseases (Viral Diseases) 01/2020 - 01/2012
7	American Hemorrhagic Fever (Bolivian Hemorrhagic Fever) 01/2022 - 12/2010
5	Lassa Fever (Fever, Lassa) 03/2020 - 01/2018
5	Human Influenza (Influenza) 01/2019 - 11/2008
4	Inflammation (Inflammations) 01/2021 - 01/2017
4	Viral Hemorrhagic Fevers (Viral Hemorrhagic Fever) 01/2020 - 02/2014
4	Porcine Reproductive and Respiratory Syndrome (PRRS) 01/2020 - 01/2017
4	Arenaviridae Infections 10/2019 - 12/2013
4	Venezuelan Equine Encephalomyelitis 11/2011 - 06/2005
3	Fever (Fevers) 01/2021 - 01/2013
3	Zika Virus Infection 01/2018 - 01/2016
3	Encephalitis (Encephalitis, Rasmussen) 01/2016 - 06/2009
3	Viremia 11/2011 - 07/2005
2	Hearing Loss (Hearing Impairment) 01/2019 - 12/2015
2	RNA Virus Infections 01/2019 - 10/2017
2	Ebola Hemorrhagic Fever 01/2018 - 01/2015
2	Neurocognitive Disorders (Clerambault Syndrome) 01/2018 - 01/2016
2	West Nile Fever 01/2017 - 11/2011
2	Viral Encephalitis 11/2011 - 06/2009
2	Influenza in Birds (Avian Flu) 09/2009 - 04/2008
2	Alphavirus Infections 07/2008 - 11/2006
2	Eastern Equine Encephalomyelitis 10/2007 - 09/2005
1	Anosmia 12/2022
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2022
1	Weight Loss (Weight Reduction) 01/2021
1	Bites and Stings (Sting) 01/2020
1	Gliosis 01/2018
1	Bacterial Infections (Bacterial Infection) 10/2016
1	Severe Fever with Thrombocytopenia Syndrome 02/2014
1	Carcinoma (Carcinomatosis) 01/2014

Drug/Important Bio-Agent (IBA)

33	VaccinesIBA 11/2022 - 03/2006
14	Antiviral Agents (Antivirals)IBA 11/2022 - 08/2008
14	InterferonsIBA 01/2020 - 12/2010
11	Proteins (Proteins, Gene)FDA Link 05/2022 - 03/2006
9	CytokinesIBA 01/2021 - 09/2008
7	Interferon Type IIBA 04/2020 - 01/2012
6	Glycoproteins (Glycoprotein)IBA 01/2022 - 07/2005
6	Neutralizing AntibodiesIBA 01/2020 - 10/2007
5	RNA (Ribonucleic Acid)IBA 05/2022 - 01/2016
5	Pharmaceutical PreparationsIBA 01/2022 - 01/2015
4	Pattern Recognition ReceptorsIBA 01/2020 - 10/2017
4	Double-Stranded RNA (RNA, Double Stranded)IBA 01/2020 - 06/2013
3	Ibuprofen (Motrin)FDA LinkGeneric 01/2020 - 01/2015
3	Protein Kinases (Protein Kinase)IBA 01/2020 - 10/2017
3	Viral RNAIBA 01/2019 - 10/2017
3	AntibodiesIBA 01/2018 - 06/2005
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 06/2013
2	Small Interfering RNA (siRNA)IBA 01/2022 - 06/2013
2	LigandsIBA 01/2021 - 01/2017
2	emvododstatIBA 01/2021 - 08/2020
2	EpitopesIBA 01/2020 - 06/2005
2	ChemokinesIBA 01/2020 - 05/2013
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2017
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2020 - 01/2019
2	Attenuated VaccinesIBA 01/2020 - 01/2012
2	Ribavirin (Virazole)FDA LinkGeneric 01/2018 - 01/2017
2	Influenza Vaccines (Influenza Vaccine)FDA Link 01/2017 - 01/2016
2	Hemagglutinins (Hemagglutinin)IBA 01/2016 - 11/2012
2	LuciferasesIBA 12/2012 - 11/2011
2	peramivirIBA 05/2012 - 04/2008
2	ImmunosorbentsIBA 11/2006 - 06/2005
2	EnzymesIBA 11/2006 - 06/2005
1	DNA Glycosylases (DNA Glycosylase)IBA 05/2022
1	Apoptosis Regulatory ProteinsIBA 01/2022
1	salicylanilideIBA 01/2021
1	SalicylanilidesIBA 01/2021
1	Polysaccharides (Glycans)IBA 01/2021
1	Disinfectants (Biocides)IBA 05/2020
1	Fentanyl (Sublimaze)FDA LinkGeneric 01/2020
1	ORALIT (ORS)IBA 01/2020
1	Opioid Receptors (Opioid Receptor)IBA 01/2020
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 01/2020
1	Guanethidine FDA Link 01/2019
1	IFIH1 Interferon-Induced HelicaseIBA 01/2019
1	cycrimineIBA 01/2019
1	AdamantaneIBA 01/2019
1	Cholinergic Antagonists (Anticholinergics)IBA 01/2019
1	Ion Channels (Ion Channel)IBA 01/2019
1	Cocaine (Cocaine HCl)IBA 01/2018
1	Eukaryotic Initiation Factor-2 (EIF 2)IBA 10/2017
1	Peptide Initiation Factors (Initiation Factor)IBA 10/2017
1	Anti-Bacterial Agents (Antibiotics)IBA 10/2016
1	Ligases (Synthetase)IBA 12/2015
1	Histones (Histone)IBA 12/2015
1	UbiquitinIBA 12/2015
1	Peptide Hydrolases (Proteases)FDA Link 12/2015
1	Interferon Receptors (Interferon Receptor)IBA 06/2014
1	Interferon-betaIBA 02/2014
1	PhosphatidylserinesIBA 01/2014
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2014
1	Caspase 3 (Caspase-3)IBA 01/2014
1	Small Nuclear RNA (snRNA)IBA 06/2013

Therapy/Procedure

11	Therapeutics 12/2022 - 01/2019
2	Immunomodulation 01/2020 - 06/2013
1	Self Administration (Administration, Self) 01/2020
1	Drug Therapy (Chemotherapy) 01/2017
1	Off-Label Use 01/2017
1	Highly Active Antiretroviral Therapy (HAART) 01/2016